How to prepare a chiral Grignard reagent: a theoretical proposal.
نویسندگان
چکیده
It is shown that two competitive pathways (T2 vs T4) exist for Grignard reagent formation. While the nonradical pathway T2 leads to retention of the configuration, the radical pathway T4 gives racemization. Our calculations suggest the way that T2 can be enhanced, which should be of significance to prompt new synthesis approaches for the preparation of chiral Grignard reagents.
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عنوان ژورنال:
- Organic letters
دوره 13 8 شماره
صفحات -
تاریخ انتشار 2011